The Total c-Src cellular assay monitors total c-Src and is used as a normalization assay with the phospho-c-Src kit. This protein is a member of the Src kinase family and shares a high degree of sequence identity with the ten other members. This protein is a membrane-associated, non-receptor tyrosine kinase. Its autophosphorylation on the residue Tyr419 indicates its full activation. c-Src kinase is over-expressed and highly activated in many human cancers, making it a promising target for cancer therapy.
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