HTRF (H) AUR A P-T288 KIT - 10K PTS

This HTRF cell-based assay conveniently and accurately detects human Aurora A protein (related to the AURKA gene) ubiquitously expressed in eukaryotes. Aurora A belongs to the serine/threonine Aurora kinase family (including Aurora B and Aurora C), essential for cell division via mitosis regulation especially in the process of chromosomal segregation. It is activated through the autophosphorylation of Threonine 288 residue mainly occurring from the late S-Phase through the M phase during the cellular division cycle or DNA damage response. The overexpression of the Aurora kinases in a wide range of cancers (Leukemia, Colon Cancer, Prostate Cancer, and Breast Cancer) makes them interesting candidates for the development of Aurora kinase inhibitors (AKIs).