HTRF (H / M)

The Ikaros zinc-finger (IKZF) family of transcription factors are essential regulators of lymphopoiesis. IKZF1 (Ikaros) and IKZF3 (Aiolos) function as both transcriptional repressors and activators during T and B cell differentiation, as well as in the function of mature cells. Ikaros family proteins partner with multiple complexes, including NuRD, PRC2, and transcription elongation factors. Through these associations, they can modulate gene expression profiles and the chromatin state. The overexpression of these proteins has been linked to sustaining cancer cell proliferation and survival, such as malignant plasma cells and multiple myeloma.Among the therapeutic strategies investigated to fight cancers, the use of IMIDs (immunomodulatory imide drugs) and their derivatives, termed CELMoDs (Cereblon E3 Ligase Modulatory Drugs) has become a popular strategy. By binding to CRBN, these compounds induce the ubiquitination of targeted proteins and promote their subsequent degradation. CELMoDs targeting IKZF1 and IKZF3 have shown promising anti-tumor activity in multiple myeloma cell models.