HTRF JAK3 TOTAL KIT - 50K PTS

The Human Total JAK3 detection assay monitors cellular JAK3 protein levels.

The Janus family kinases JAK1, JAK2, JAK3, and TYK2 are non-receptor protein tyrosine kinases that signal downstream cytokine receptors (mainly IL-R and IFN-R) and activate the STAT transcription factors. A specific JAK/JAK combination associates with a specific receptor and gives specificity to the downstream JAK/STAT signaling pathway. JAK3, in combination with JAK1, associates exclusively with the IL-2Rγ family receptors, and triggers the activation of the transcription factors STAT1, STAT3, STAT5, and STAT6 to regulate lymphocyte maturation, survival, activation, and differentiation.

JAK3 dysregulation has been reported in cancer and immune disorders. The main therapeutic strategies consist in developing potent and selective inhibitors/degraders of JAK3.